IL-17 in the immunopathogenesis of spondyloarthritis
نویسندگان
چکیده
منابع مشابه
IL-17 in spondyloarthritis: is the T-party over?
The past decade has witnessed significant progress in revealing an important role for IL-17 in the pathogenesis of several immune-mediated inflammatory diseases. Recent studies have provided new insights into the cellular source of IL-17, originally identified as the signature cytokine of a distinct CD4(+) T-cell subset known as Th17. Accumulating evidence suggests that the majority of the IL-1...
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Spondyloarthritides, or SpA, form a cluster of chronic inflammatory diseases with the axial skeleton as the most typical disease localisation, although extra-articular manifestations such as intestinal inflammation may frequently occur during the course of the disease. This review summarises recent progress in our understanding of the immunopathogenesis of SpA with special emphasis on the cellu...
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Disclosure: Atul Deodhar has participated in advisory boards and received research grants from AbbVie, Amgen, Janssen, Novartis, Pfizer, and UCB. Dirk Elewaut has received a research grant, consultation fees, and speaker honoraria from AbbVie, Boehringer Ingelheim, BMS, and Merck. Dominique Baeten has received consultation fees from AbbVie, Pfizer, MSD, UCB, Janssen, Novartis, Eli Lilly, Boehri...
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INTRODUCTION Uveitis, or intraocular inflammatory disease, is a frequent extra-articular manifestation of several forms of arthritis. Despite the frequent co-occurrence of uveitis and arthritis, little is understood of the eye's predisposition to this disease. We recently described a previously unreported uveitis in a murine model of spondyloarthropathy triggered by autoimmunity to aggrecan, a ...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2018
ISSN: 1759-4790,1759-4804
DOI: 10.1038/s41584-018-0044-2